Antidepressants have their own way of suppressing pain. They change the perception of pain in the spinal cord as well as in the brain. A successful pain therapy is not only restricted to direct treatment at the cause of pain's origin, but also in the central nervous system and in the brain. For this reason, antidepressants have proven effective in particular with patients with chronic pain, because, for instance, they raise the limit of pain perception.

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